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integrin α5β1 receptor function  (MedChemExpress)


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    MedChemExpress integrin α5β1 receptor function
    Inhibition of integrin <t>α5β1</t> receptor function attenuates inflammatory injury in DSS-induced colitis in mice. (A ) Body weight of each group was monitored for 10 days (n = 6). ( B ) Representative images of colon and colon length were measured in each group on day 10 (n = 6). ( C ) Representative H&E stained micrographs of colon in each group and quantitative assessment of colon injury using histopathology scores (n = 6); black arrowheads indicate inflammatory cell infiltration (scale bar: 25 μm; original. ( D ) Representative immunohistochemical staining of integrin α5β1 + cells in colonic mucosa (scale bar: 25 μm; original magnification ×400) and quantification of integrin α5β1 + cells per high-power field (n = 6), with black arrows indicating positive cells. ( E ) ELISA assay was performed to examine the serum concentrations of pro-inflammatory cytokines CXCL1, IL-6, TNF-α and IL-1β (n = 6). Statistical analysis was performed by one-way ANOVA. ns: not significant; *: p<0.05; ***: p<0.001.
    Integrin α5β1 Receptor Function, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 6 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/integrin α5β1 receptor function/product/MedChemExpress
    Average 93 stars, based on 6 article reviews
    integrin α5β1 receptor function - by Bioz Stars, 2026-06
    93/100 stars

    Images

    1) Product Images from "The eNAMPT-Integrin α5β1 Axis Mediates Neutrophil-Endothelial Cell Interactions Driving Inflammation in Ulcerative Colitis"

    Article Title: The eNAMPT-Integrin α5β1 Axis Mediates Neutrophil-Endothelial Cell Interactions Driving Inflammation in Ulcerative Colitis

    Journal: Journal of Inflammation Research

    doi: 10.2147/JIR.S554975

    Inhibition of integrin α5β1 receptor function attenuates inflammatory injury in DSS-induced colitis in mice. (A ) Body weight of each group was monitored for 10 days (n = 6). ( B ) Representative images of colon and colon length were measured in each group on day 10 (n = 6). ( C ) Representative H&E stained micrographs of colon in each group and quantitative assessment of colon injury using histopathology scores (n = 6); black arrowheads indicate inflammatory cell infiltration (scale bar: 25 μm; original. ( D ) Representative immunohistochemical staining of integrin α5β1 + cells in colonic mucosa (scale bar: 25 μm; original magnification ×400) and quantification of integrin α5β1 + cells per high-power field (n = 6), with black arrows indicating positive cells. ( E ) ELISA assay was performed to examine the serum concentrations of pro-inflammatory cytokines CXCL1, IL-6, TNF-α and IL-1β (n = 6). Statistical analysis was performed by one-way ANOVA. ns: not significant; *: p<0.05; ***: p<0.001.
    Figure Legend Snippet: Inhibition of integrin α5β1 receptor function attenuates inflammatory injury in DSS-induced colitis in mice. (A ) Body weight of each group was monitored for 10 days (n = 6). ( B ) Representative images of colon and colon length were measured in each group on day 10 (n = 6). ( C ) Representative H&E stained micrographs of colon in each group and quantitative assessment of colon injury using histopathology scores (n = 6); black arrowheads indicate inflammatory cell infiltration (scale bar: 25 μm; original. ( D ) Representative immunohistochemical staining of integrin α5β1 + cells in colonic mucosa (scale bar: 25 μm; original magnification ×400) and quantification of integrin α5β1 + cells per high-power field (n = 6), with black arrows indicating positive cells. ( E ) ELISA assay was performed to examine the serum concentrations of pro-inflammatory cytokines CXCL1, IL-6, TNF-α and IL-1β (n = 6). Statistical analysis was performed by one-way ANOVA. ns: not significant; *: p<0.05; ***: p<0.001.

    Techniques Used: Inhibition, Staining, Histopathology, Immunohistochemical staining, Enzyme-linked Immunosorbent Assay



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    integrin α5β1 receptor function  (MedChemExpress)
    93
    MedChemExpress integrin α5β1 receptor function
    Inhibition of integrin <t>α5β1</t> receptor function attenuates inflammatory injury in DSS-induced colitis in mice. (A ) Body weight of each group was monitored for 10 days (n = 6). ( B ) Representative images of colon and colon length were measured in each group on day 10 (n = 6). ( C ) Representative H&E stained micrographs of colon in each group and quantitative assessment of colon injury using histopathology scores (n = 6); black arrowheads indicate inflammatory cell infiltration (scale bar: 25 μm; original. ( D ) Representative immunohistochemical staining of integrin α5β1 + cells in colonic mucosa (scale bar: 25 μm; original magnification ×400) and quantification of integrin α5β1 + cells per high-power field (n = 6), with black arrows indicating positive cells. ( E ) ELISA assay was performed to examine the serum concentrations of pro-inflammatory cytokines CXCL1, IL-6, TNF-α and IL-1β (n = 6). Statistical analysis was performed by one-way ANOVA. ns: not significant; *: p<0.05; ***: p<0.001.
    Integrin α5β1 Receptor Function, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/integrin α5β1 receptor function/product/MedChemExpress
    Average 93 stars, based on 1 article reviews
    integrin α5β1 receptor function - by Bioz Stars, 2026-06
    93/100 stars
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    Image Search Results


    Inhibition of integrin α5β1 receptor function attenuates inflammatory injury in DSS-induced colitis in mice. (A ) Body weight of each group was monitored for 10 days (n = 6). ( B ) Representative images of colon and colon length were measured in each group on day 10 (n = 6). ( C ) Representative H&E stained micrographs of colon in each group and quantitative assessment of colon injury using histopathology scores (n = 6); black arrowheads indicate inflammatory cell infiltration (scale bar: 25 μm; original. ( D ) Representative immunohistochemical staining of integrin α5β1 + cells in colonic mucosa (scale bar: 25 μm; original magnification ×400) and quantification of integrin α5β1 + cells per high-power field (n = 6), with black arrows indicating positive cells. ( E ) ELISA assay was performed to examine the serum concentrations of pro-inflammatory cytokines CXCL1, IL-6, TNF-α and IL-1β (n = 6). Statistical analysis was performed by one-way ANOVA. ns: not significant; *: p<0.05; ***: p<0.001.

    Journal: Journal of Inflammation Research

    Article Title: The eNAMPT-Integrin α5β1 Axis Mediates Neutrophil-Endothelial Cell Interactions Driving Inflammation in Ulcerative Colitis

    doi: 10.2147/JIR.S554975

    Figure Lengend Snippet: Inhibition of integrin α5β1 receptor function attenuates inflammatory injury in DSS-induced colitis in mice. (A ) Body weight of each group was monitored for 10 days (n = 6). ( B ) Representative images of colon and colon length were measured in each group on day 10 (n = 6). ( C ) Representative H&E stained micrographs of colon in each group and quantitative assessment of colon injury using histopathology scores (n = 6); black arrowheads indicate inflammatory cell infiltration (scale bar: 25 μm; original. ( D ) Representative immunohistochemical staining of integrin α5β1 + cells in colonic mucosa (scale bar: 25 μm; original magnification ×400) and quantification of integrin α5β1 + cells per high-power field (n = 6), with black arrows indicating positive cells. ( E ) ELISA assay was performed to examine the serum concentrations of pro-inflammatory cytokines CXCL1, IL-6, TNF-α and IL-1β (n = 6). Statistical analysis was performed by one-way ANOVA. ns: not significant; *: p<0.05; ***: p<0.001.

    Article Snippet: The groups of DSS-fed mice were: the UC model group; the anti-Ly6G group, which was injected intraperitoneally with anti-Ly6G antibody (1.25 mg/kg, Selleck, USA) every 2 days to deplete neutrophils; the Daporinad group, which was injected intraperitoneally with Daporinad (2.4 mg/kg, MedChemExpres, USA) every day to inhibit NAMPT activity and reduce eNAMPT levels; ATN-161 group, daily intraperitoneal injection of ATN-161 to block integrin α5β1 receptor function (1 mg/kg, MCE).

    Techniques: Inhibition, Staining, Histopathology, Immunohistochemical staining, Enzyme-linked Immunosorbent Assay